| FMR LLC | 29,093,899 | $840.2m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,137,638 | $235.0m | 2.5% |
| MONTANOVA CAPITAL, LLC | 7,070,000 | $204.2m | 3.7% |
| HHLR ADVISORS, LTD. | 5,984,550 | $172.8m | 20.8% |
| BlackRock, Inc. | 4,726,534 | $136.5m | 0.0% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,430,063 | $127.9m | 0.4% |
| Assenagon Asset Management S.A. | 3,830,112 | $110.6m | 0.1% |
| GOLDMAN SACHS GROUP INC | 3,662,315 | $105.8m | 0.0% |
| Point72 Asset Management, L.P. | 3,076,124 | $88.8m | 0.1% |
| Kynam Capital Management, LP | 3,001,205 | $86.7m | 4.8% |
| Artisan Partners Limited Partnership | 1,559,441 | $45.0m | 0.1% |
| STATE STREET CORP | 1,498,704 | $43.3m | 0.0% |
| Capital International Investors | 1,420,654 | $41.0m | 0.0% |
| MORGAN STANLEY | 1,394,531 | $40.3m | 0.0% |
| Soleus Capital Management, L.P. | 1,205,000 | $34.8m | 1.2% |
| Davern Capital Partners, LP | 1,191,522 | $34.4m | 5.9% |
| Driehaus Capital Management LLC | 1,158,808 | $33.5m | 0.2% |
| RENAISSANCE TECHNOLOGIES LLC | 1,000,200 | $28.9m | 0.0% |
| Ghisallo Capital Management LLC | 1,000,000 | $28.9m | 0.6% |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC | 917,266 | $26.5m | 9.1% |
| JOHNSON & JOHNSON | 814,586 | $23.5m | 2.9% |
| IvyRock Asset Management (HK) Ltd | 801,000 | $23.1m | 13.1% |
| EcoR1 Capital, LLC | 800,000 | $23.1m | 1.1% |
| JPMORGAN CHASE & CO | 766,364 | $22.5m | 0.0% |
| Squarepoint Ops LLC | 769,252 | $22.2m | 0.0% |