| GILEAD SCIENCES, INC. | 16,707,477 | $500.2m | 30.3% |
| TANG CAPITAL MANAGEMENT LLC | 3,785,991 | $113.5m | 5.2% |
| Madison Avenue Partners, LP | 3,447,807 | $103.4m | 4.4% |
| Prosight Management, LP | 2,043,344 | $61.3m | 10.6% |
| EcoR1 Capital, LLC | 1,667,119 | $50.0m | 2.4% |
| AMERIPRISE FINANCIAL INC | 1,272,249 | $38.1m | 0.0% |
| DME Capital Management, LP | 482,746 | $14.5m | 0.4% |
| RENAISSANCE TECHNOLOGIES LLC | 407,800 | $12.2m | 0.0% |
| BlackRock, Inc. | 338,152 | $10.1m | 0.0% |
| Point72 Asset Management, L.P. | 269,814 | $8.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 197,844 | $5.9m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 181,090 | $5.4m | 0.0% |
| UBS Group AG | 168,148 | $5.0m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,886 | $4.6m | 0.0% |
| DAFNA Capital Management LLC | 130,175 | $3.9m | 0.7% |
| CITADEL ADVISORS LLC | 88,343 | $2.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 81,749 | $2.5m | 0.0% |
| NORGES BANK | 76,879 | $2.3m | 0.0% |
| ALPS ADVISORS INC | 65,523 | $2.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 56,581 | $1.7m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 40,804 | $1.2m | 0.0% |
| BAROMETER CAPITAL MANAGEMENT INC. | 40,800 | $1.2m | 0.3% |
| MORGAN STANLEY | 37,682 | $1.1m | 0.0% |
| Schonfeld Strategic Advisors LLC | 32,597 | $977,256 | 0.0% |
| MARSHALL WACE, LLP | 32,399 | $971,321 | 0.0% |