| PERCEPTIVE ADVISORS LLC | 1,859,322 | $17.1m | 0.3% |
| Kalehua Capital Management LLC | 787,402 | $7.2m | 2.3% |
| ADAR1 Capital Management, LLC | 777,100 | $7.1m | 0.3% |
| ACORN CAPITAL ADVISORS, LLC | 634,539 | $5.8m | 1.6% |
| NEA Management Company, LLC | 464,398 | $4.3m | 0.3% |
| Commodore Capital LP | 464,398 | $4.3m | 0.3% |
| TCG Crossover Management, LLC | 464,398 | $4.3m | 0.1% |
| Spruce Street Capital LP | 393,701 | $3.6m | 0.7% |
| Blackstone Inc. | 324,638 | $3.0m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | $2.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 275,233 | $2.5m | 0.0% |
| Seven Fleet Capital Management LP | 154,153 | $1.4m | 0.2% |
| Simplify Asset Management Inc. | 149,279 | $1.4m | 0.0% |
| Propel Bio Management, LLC | 149,279 | $1.4m | 0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 80,418 | $739,513 | 0.0% |
| BlackRock, Inc. | 79,186 | $727,719 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 77,424 | $711,527 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 42,814 | $393,461 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 32,557 | $299,199 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 32,450 | $298,216 | 0.0% |
| Laird Norton Wetherby Trust Company, LLC | 21,818 | $200,508 | 0.0% |
| STATE STREET CORP | 16,337 | $150,137 | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 14,728 | $135,351 | 0.0% |
| NORTHERN TRUST CORP | 14,394 | $132,281 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 13,276 | $122,006 | 0.0% |