| Artal Group S.A. | 175,156,062 | $420.4m | 45.1% |
| FMR LLC | 51,782,045 | $124.3m | 0.0% |
| Siren, L.L.C. | 44,303,518 | $106.3m | 2.2% |
| Sessa Capital IM, L.P. | 18,960,836 | $45.5m | 0.8% |
| BlackRock, Inc. | 17,348,741 | $41.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 9,901,208 | $23.8m | 0.0% |
| Point72 Asset Management, L.P. | 8,251,325 | $19.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,244,372 | $15.0m | 0.0% |
| STATE STREET CORP | 4,917,769 | $11.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,357,749 | $5.7m | 0.0% |
| NORTHERN TRUST CORP | 1,968,619 | $4.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,956,775 | $4.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,634,571 | $3.9m | 0.0% |
| CITADEL ADVISORS LLC | 1,601,182 | $3.8m | 0.0% |
| Ishara Investments LP | 1,271,000 | $3.1m | 2.2% |
| MILLENNIUM MANAGEMENT LLC | 1,134,229 | $2.7m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,127,000 | $2.7m | 0.0% |
| MACKENZIE FINANCIAL CORP | 963,354 | $2.3m | 0.0% |
| ADAR1 Capital Management, LLC | 750,000 | $1.8m | 0.1% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 696,776 | $1.7m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 696,617 | $1.7m | 0.0% |
| UBS Group AG | 684,713 | $1.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 643,444 | $1.5m | 0.0% |
| Nuveen, LLC | 586,664 | $1.4m | 0.0% |
| Bank of New York Mellon Corp | 568,706 | $1.4m | 0.0% |