| ARCH Venture Management, LLC | 3,247,162 | $45.5m | 4.1% |
| GSK plc | 1,512,659 | $21.3m | 3.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 786,774 | $11.1m | 0.0% |
| Orland Properties Ltd | 754,698 | $10.6m | 5.2% |
| BlackRock, Inc. | 724,342 | $10.2m | 0.0% |
| Almitas Capital LLC | 581,407 | $8.2m | 2.0% |
| Foresite Capital Management V, LLC | 476,386 | $6.7m | 1.8% |
| MILLENNIUM MANAGEMENT LLC | 367,473 | $5.2m | 0.0% |
| Opaleye Management Inc. | 344,025 | $4.8m | 0.4% |
| venBio Partners LLC | 337,697 | $4.7m | 0.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 310,636 | $4.4m | 0.0% |
| Alphabet Inc. | 293,256 | $4.1m | 0.0% |
| STATE STREET CORP | 185,322 | $2.6m | 0.0% |
| HSG Holding Ltd | 152,299 | $2.1m | 0.2% |
| RENAISSANCE TECHNOLOGIES LLC | 130,190 | $1.8m | 0.0% |
| NORTHERN TRUST CORP | 118,500 | $1.7m | 0.0% |
| Qube Research & Technologies Ltd | 110,531 | $1.6m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,570 | $1.5m | 0.0% |
| MARSHALL WACE, LLP | 106,300 | $1.5m | 0.0% |
| Velan Capital Investment Management LP | 105,000 | $1.5m | 0.9% |
| VANGUARD FIDUCIARY TRUST CO | 93,095 | $1.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 91,891 | $1.3m | 0.0% |
| MIC Capital Management UK LLP | 87,028 | $1.2m | 0.3% |
| GOLDMAN SACHS GROUP INC | 86,779 | $1.2m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 68,315 | $957,066 | 0.0% |