| Jupiter Topco LLC | 1,312,129 | $121.7m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 667,207 | $61.8m | 0.5% |
| BlackRock, Inc. | 348,819 | $32.3m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 323,745 | $30.0m | 0.3% |
| Saturn V Capital Management LP | 311,976 | $28.9m | 4.1% |
| Siren, L.L.C. | 270,118 | $25.0m | 0.5% |
| ADAR1 Capital Management, LLC | 217,595 | $20.1m | 0.9% |
| Polar Capital Holdings Plc | 214,469 | $19.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 209,711 | $19.4m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 209,195 | $19.4m | 0.0% |
| TCG Crossover Management, LLC | 203,327 | $18.8m | 0.5% |
| WELLINGTON MANAGEMENT GROUP LLP | 158,437 | $14.7m | 0.0% |
| ORBIMED ADVISORS LLC | 157,423 | $14.6m | 0.3% |
| Candriam S.C.A. | 143,339 | $13.3m | 0.1% |
| Balyasny Asset Management L.P. | 134,543 | $12.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 112,578 | $10.4m | 0.0% |
| Alyeska Investment Group, L.P. | 100,000 | $9.3m | 0.0% |
| STATE STREET CORP | 92,551 | $8.6m | 0.0% |
| Vivo Capital, LLC | 90,500 | $8.4m | 0.8% |
| Driehaus Capital Management LLC | 84,040 | $7.8m | 0.0% |
| Bank of New York Mellon Corp | 76,942 | $7.1m | 0.0% |
| Vestal Point Capital, LP | 75,727 | $7.0m | 0.2% |
| Longaeva Partners L.P. | 55,834 | $5.2m | 0.1% |
| NEUBERGER BERMAN GROUP LLC | 55,194 | $5.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 50,311 | $4.7m | 0.0% |