| NOVO HOLDINGS A/S | 3,686,622 | $132.1m | 7.7% |
| FCPM III SERVICES B.V. | 3,226,400 | $115.6m | 15.4% |
| T. Rowe Price Investment Management, Inc. | 2,781,728 | $99.7m | 0.1% |
| GOLDMAN SACHS GROUP INC | 1,948,312 | $69.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,422,935 | $51.0m | 0.0% |
| BlackRock, Inc. | 1,025,134 | $36.7m | 0.0% |
| Nan Fung Group Holdings Ltd | 971,253 | $34.8m | 26.5% |
| 5AM Venture Management, LLC | 950,011 | $34.0m | 11.8% |
| Sanofi | 912,041 | $32.7m | 6.1% |
| STATE STREET CORP | 852,150 | $30.5m | 0.0% |
| FMR LLC | 823,556 | $29.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 784,150 | $28.1m | 0.0% |
| Blue Owl Capital Holdings LP | 729,929 | $26.2m | 3.9% |
| Paradigm Biocapital Advisors LP | 685,852 | $24.6m | 0.5% |
| Pivotal bioVenture Partners Investment Advisor LLC | 611,446 | $21.9m | 7.1% |
| Velan Capital Investment Management LP | 492,893 | $17.7m | 10.8% |
| Siren, L.L.C. | 450,000 | $16.1m | 0.3% |
| Capital World Investors | 415,730 | $14.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 402,051 | $14.4m | 0.0% |
| BAKER BROS. ADVISORS LP | 364,705 | $13.1m | 0.1% |
| DAFNA Capital Management LLC | 171,006 | $6.1m | 1.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 170,862 | $6.1m | 0.0% |
| Freestone Grove Partners LP | 168,912 | $6.1m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 136,818 | $4.9m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 128,841 | $4.6m | 0.0% |