| FEDERATED HERMES, INC. | 4,670,426 | $25.9m | 0.0% |
| Jupiter Topco LLC | 4,386,027 | $24.3m | 0.0% |
| Vivo Capital, LLC | 4,322,747 | $24.0m | 2.2% |
| Balyasny Asset Management L.P. | 4,257,000 | $23.6m | 0.0% |
| Logos Global Management LP | 3,288,777 | $18.3m | 0.8% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 2,365,000 | $13.1m | 0.1% |
| BlackRock, Inc. | 2,240,578 | $12.4m | 0.0% |
| Ally Bridge Group (NY) LLC | 2,175,802 | $12.1m | 10.7% |
| Foresite Capital Management VI LLC | 1,985,584 | $11.0m | 1.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,892,807 | $10.5m | 0.0% |
| Spruce Street Capital LP | 1,655,500 | $9.2m | 1.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,419,000 | $7.9m | 0.0% |
| Trails Edge Capital Partners, LP | 1,419,000 | $7.9m | 1.3% |
| Seven Fleet Capital Management LP | 1,001,373 | $5.6m | 0.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 974,236 | $5.4m | 0.0% |
| DV EQUITIES, LLC | 754,397 | $4.2m | 0.6% |
| ACUTA CAPITAL PARTNERS, LLC | 709,500 | $3.9m | 2.7% |
| MILLENNIUM MANAGEMENT LLC | 533,602 | $3.0m | 0.0% |
| STATE STREET CORP | 424,915 | $2.4m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 302,604 | $1.7m | 0.0% |
| NORTHERN TRUST CORP | 292,117 | $1.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 234,754 | $1.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 143,954 | $798,945 | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 113,625 | $630,619 | 0.0% |
| Bank of New York Mellon Corp | 75,580 | $419,468 | 0.0% |