| Nantahala Capital Management, LLC | 6,752,968 | $4.7m | 0.1% |
| Rosalind Advisors, Inc. | 3,905,743 | $2.7m | 1.0% |
| Aberdeen Group plc | 3,698,364 | $2.6m | 0.0% |
| ORBIMED ADVISORS LLC | 3,133,405 | $2.2m | 0.0% |
| Parkman Healthcare Partners LLC | 2,416,518 | $1.7m | 0.2% |
| MARSHALL WACE, LLP | 1,860,405 | $1.3m | 0.0% |
| Soleus Capital Management, L.P. | 1,045,708 | $732,100 | 0.0% |
| PURA VIDA INVESTMENTS, LLC | 450,517 | $315,407 | 0.9% |
| INGALLS & SNYDER LLC | 368,800 | $258,000 | 0.0% |
| Affiance Financial, LLC | 250,370 | $175,284 | 0.0% |
| Velan Capital Investment Management LP | 148,138 | $103,711 | 0.1% |
| BlackRock, Inc. | 122,993 | $86,108 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 112,832 | $78,994 | 0.0% |
| Creative Planning | 108,964 | $76,286 | 0.0% |
| Schonfeld Strategic Advisors LLC | 99,275 | $69,502 | 0.0% |
| HRT FINANCIAL LP | 59,754 | $41,000 | 0.0% |
| XTX Topco Ltd | 49,029 | $34,325 | 0.0% |
| Centiva Capital, LP | 44,123 | $30,891 | 0.0% |
| Cambridge Investment Research Advisors, Inc. | 40,332 | $28,000 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 37,677 | $26,378 | 0.0% |
| COURIER CAPITAL LLC | 30,000 | $21,003 | 0.0% |
| Mesirow Financial Investment Management, Inc. | 30,000 | $21,003 | 0.0% |
| MORGAN STANLEY | 28,371 | $19,863 | 0.0% |
| VESTIA PERSONAL WEALTH ADVISORS | 24,425 | $17,100 | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,594 | $14,418 | 0.0% |