| ARK Investment Management LLC | 16,875,684 | $285.5m | 1.9% |
| BlackRock, Inc. | 15,409,023 | $260.7m | 0.0% |
| STATE STREET CORP | 9,234,987 | $156.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,332,401 | $124.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 6,443,323 | $109.0m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,028,586 | $102.0m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 5,235,348 | $88.6m | 0.1% |
| FMR LLC | 4,773,034 | $80.8m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 4,526,926 | $76.6m | 0.7% |
| REGENERON PHARMACEUTICALS, INC. | 3,702,995 | $62.7m | 35.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,631,061 | $61.4m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 3,280,760 | $55.5m | 0.0% |
| Sumitomo Mitsui Trust Group, Inc. | 2,897,529 | $49.0m | 0.0% |
| Amova Asset Management Americas, Inc. | 2,897,529 | $49.0m | 0.6% |
| DIMENSIONAL FUND ADVISORS LP | 2,602,944 | $44.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,264,471 | $38.3m | 0.0% |
| UBS Group AG | 2,152,912 | $36.4m | 0.0% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,066,356 | $35.0m | 0.1% |
| Contrarius Group Holdings Ltd | 1,955,228 | $33.1m | 1.5% |
| JUPITER ASSET MANAGEMENT LTD | 1,849,507 | $31.3m | 0.2% |
| MORGAN STANLEY | 1,731,905 | $29.3m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,500,000 | $25.4m | 0.3% |
| RENAISSANCE TECHNOLOGIES LLC | 1,400,004 | $23.7m | 0.0% |
| NORTHERN TRUST CORP | 1,272,136 | $21.5m | 0.0% |
| HRT FINANCIAL LP | 1,243,317 | $21.0m | 0.0% |