| JPMORGAN CHASE & CO | 12,865,346 | $3.5bn | 0.2% |
| BlackRock, Inc. | 10,914,608 | $3.0bn | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,021,895 | $2.4bn | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,228,216 | $1.7bn | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 5,782,640 | $1.6bn | 0.1% |
| FMR LLC | 5,451,396 | $1.5bn | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 4,040,738 | $1.1bn | 0.2% |
| STATE STREET CORP | 3,655,618 | $992.3m | 0.0% |
| Duquesne Family Office LLC | 3,186,306 | $864.9m | 16.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,750,013 | $744.6m | 0.0% |
| FRANKLIN RESOURCES INC | 2,725,903 | $739.9m | 0.2% |
| Castle Hook Partners LP | 2,596,276 | $704.8m | 3.2% |
| COATUE MANAGEMENT LLC | 2,505,090 | $680.0m | 1.4% |
| AQR CAPITAL MANAGEMENT LLC | 2,344,570 | $628.1m | 0.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 2,218,366 | $602.2m | 2.8% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,971,391 | $535.1m | 0.2% |
| NORGES BANK | 1,828,122 | $496.2m | 0.0% |
| FRED ALGER MANAGEMENT, LLC | 1,778,009 | $482.6m | 1.6% |
| GOLDMAN SACHS GROUP INC | 1,720,152 | $466.9m | 0.0% |
| Sofinnova Investments, Inc. | 1,550,280 | $420.8m | 21.8% |
| Capital World Investors | 1,504,387 | $408.4m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,503,706 | $408.2m | 0.2% |
| MAVERICK CAPITAL LTD | 1,356,663 | $368.3m | 3.3% |
| D. E. Shaw & Co., Inc. | 1,279,255 | $347.3m | 0.2% |
| MORGAN STANLEY | 1,274,287 | $345.9m | 0.0% |