| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,248,450 | $2.1bn | 22.2% |
| Paradigm Biocapital Advisors LP | 5,924,433 | $731.7m | 13.7% |
| BlackRock, Inc. | 5,585,619 | $689.8m | 0.0% |
| HBK INVESTMENTS L P | 3,483,100 | $430.2m | 4.2% |
| FIL Ltd | 2,946,506 | $363.9m | 0.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,589,282 | $319.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,459,118 | $303.7m | 0.0% |
| STATE STREET CORP | 2,091,044 | $258.2m | 0.0% |
| Deep Track Capital, LP | 1,783,322 | $220.2m | 3.2% |
| GLAZER CAPITAL, LLC | 1,769,665 | $218.6m | 5.4% |
| GOLDMAN SACHS GROUP INC | 1,640,833 | $202.6m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,580,505 | $195.2m | 2.9% |
| FMR LLC | 1,417,590 | $175.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,407,353 | $173.8m | 0.0% |
| BARCLAYS PLC | 1,268,265 | $156.6m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,246,456 | $153.9m | 1.3% |
| Pentwater Capital Management LP | 1,175,000 | $145.1m | 0.9% |
| Bellevue Group AG | 1,053,268 | $130.1m | 2.7% |
| Balyasny Asset Management L.P. | 1,037,583 | $128.1m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 876,830 | $108.3m | 0.0% |
| First Trust Capital Management L.P. | 836,918 | $103.4m | 6.0% |
| MORGAN STANLEY | 681,225 | $84.1m | 0.0% |
| NEXPOINT ASSET MANAGEMENT, L.P. | 617,820 | $76.3m | 5.1% |
| AQR Arbitrage LLC | 601,633 | $74.3m | 1.1% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 585,583 | $72.3m | 0.2% |