| TANG CAPITAL MANAGEMENT LLC | 1,550,000 | $28.5m | 1.3% |
| BlackRock, Inc. | 1,001,285 | $18.4m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,000,000 | $18.4m | 0.3% |
| Soleus Capital Management, L.P. | 1,000,000 | $18.4m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 872,482 | $16.0m | 0.0% |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 777,078 | $14.3m | 4.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 432,273 | $8.0m | 0.0% |
| Occam Crest Management LP | 357,147 | $7.4m | 3.8% |
| SPHERA FUNDS MANAGEMENT LTD. | 382,945 | $7.0m | 0.9% |
| BALDWIN WEALTH PARTNERS LLC/MA | 382,015 | $7.0m | 0.5% |
| Alyeska Investment Group, L.P. | 275,000 | $5.1m | 0.0% |
| STATE STREET CORP | 248,198 | $4.6m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 217,286 | $4.0m | 0.0% |
| Avidity Partners Management LP | 200,000 | $3.7m | 0.6% |
| Kalehua Capital Management LLC | 200,000 | $3.7m | 1.2% |
| NORTHERN TRUST CORP | 146,714 | $2.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 127,554 | $2.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 118,297 | $2.2m | 0.0% |
| CITADEL ADVISORS LLC | 115,532 | $2.1m | 0.0% |
| OPPENHEIMER & CO INC | 73,566 | $1.4m | 0.0% |
| UBS Group AG | 69,200 | $1.3m | 0.0% |
| FORBES J M & CO LLP | 59,000 | $1.1m | 0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 57,133 | $1.1m | 0.0% |
| CIBC Bancorp USA Inc. | 67,155 | $917,661 | 0.0% |
| Informed Momentum Co LLC | 47,168 | $867,420 | 0.1% |