| RTW INVESTMENTS, LP | 9,556,063 | $41.2m | 0.4% |
| PERCEPTIVE ADVISORS LLC | 5,037,906 | $21.7m | 0.3% |
| BlackRock, Inc. | 2,510,387 | $10.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,022,916 | $8.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,007,908 | $4.4m | 0.0% |
| Alyeska Investment Group, L.P. | 1,000,000 | $4.3m | 0.0% |
| Propel Bio Management, LLC | 896,701 | $3.9m | 2.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 642,154 | $2.8m | 0.0% |
| STATE STREET CORP | 516,050 | $2.2m | 0.0% |
| RICE HALL JAMES & ASSOCIATES, LLC | 424,000 | $1.8m | 0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 349,544 | $1.5m | 0.0% |
| NORTHERN TRUST CORP | 343,640 | $1.5m | 0.0% |
| UBS Group AG | 325,773 | $1.4m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 292,253 | $1.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 274,973 | $1.2m | 0.0% |
| Knott David M Jr | 253,651 | $1.1m | 0.6% |
| Flat Footed LLC | 251,372 | $1.1m | 0.1% |
| Simplify Asset Management Inc. | 219,387 | $946,655 | 0.0% |
| GOLDMAN SACHS GROUP INC | 179,606 | $775,000 | 0.0% |
| DAFNA Capital Management LLC | 126,841 | $547,319 | 0.1% |
| RENAISSANCE TECHNOLOGIES LLC | 90,000 | $388,350 | 0.0% |
| IFP Advisors, Inc | 89,608 | $386,659 | 0.0% |
| Daytona Street Capital LLC | 96,398 | $379,336 | 0.3% |
| Bank of New York Mellon Corp | 86,103 | $371,534 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 80,600 | $347,789 | 0.0% |