| FMR LLC | 32,844,043 | $322.5m | 0.0% |
| Deep Track Capital, LP | 19,686,282 | $193.3m | 2.8% |
| BlackRock, Inc. | 19,376,555 | $190.3m | 0.0% |
| Avoro Capital Advisors LLC | 12,540,000 | $123.1m | 1.1% |
| Summer Road LLC | 12,208,296 | $119.9m | 74.5% |
| Venrock Adviser, LLC | 10,346,926 | $101.6m | 3.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,832,595 | $86.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,623,533 | $74.9m | 0.0% |
| Logos Global Management LP | 5,300,000 | $52.0m | 2.2% |
| STATE STREET CORP | 5,233,282 | $51.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,021,092 | $49.3m | 0.0% |
| Point72 Asset Management, L.P. | 3,292,193 | $32.3m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,783,367 | $27.3m | 0.0% |
| DELTEC ASSET MANAGEMENT LLC | 2,476,197 | $24.3m | 3.6% |
| Balyasny Asset Management L.P. | 2,270,707 | $22.3m | 0.0% |
| Octagon Capital Advisors LP | 2,075,000 | $20.4m | 1.8% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,973,130 | $19.4m | 0.0% |
| NORTHERN TRUST CORP | 1,799,426 | $17.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,761,754 | $17.3m | 0.0% |
| Nuveen, LLC | 1,697,274 | $16.7m | 0.0% |
| Woodline Partners LP | 1,667,609 | $16.4m | 0.1% |
| TCG Crossover Management, LLC | 1,647,752 | $16.2m | 0.4% |
| UBS Group AG | 1,551,001 | $15.2m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,550,000 | $15.2m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,533,438 | $15.1m | 0.0% |