| FMR LLC | 5,179,262 | $96.9m | 0.0% |
| SR One Capital Management, LP | 3,794,883 | $71.0m | 6.8% |
| TPG GP A, LLC | 3,690,146 | $69.0m | 1.4% |
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 3,608,443 | $67.5m | 2.8% |
| ORBIMED ADVISORS LLC | 3,001,198 | $56.2m | 1.0% |
| Sanofi | 1,991,918 | $37.3m | 7.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,046,139 | $19.6m | 0.2% |
| Sands Capital Alternatives, LLC | 875,000 | $16.4m | 2.7% |
| HHLR ADVISORS, LTD. | 831,656 | $15.6m | 1.9% |
| General Catalyst Group Management, LLC | 810,272 | $15.2m | 8.0% |
| Affinity Asset Advisors, LLC | 766,346 | $14.3m | 0.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 725,000 | $13.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 720,440 | $13.5m | 0.0% |
| Foresite Capital Management V, LLC | 713,105 | $13.3m | 3.7% |
| Vivo Capital, LLC | 575,000 | $10.8m | 1.0% |
| EcoR1 Capital, LLC | 555,555 | $10.4m | 0.5% |
| Logos Global Management LP | 521,736 | $9.8m | 0.4% |
| MARSHALL WACE, LLP | 492,697 | $9.2m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 471,987 | $8.8m | 0.0% |
| Catalio Capital Management, LP | 457,839 | $8.6m | 1.6% |
| Redmile Group, LLC | 425,000 | $8.0m | 0.5% |
| Balyasny Asset Management L.P. | 393,862 | $7.4m | 0.0% |
| Woodline Partners LP | 345,746 | $6.5m | 0.0% |
| FRANKLIN RESOURCES INC | 275,022 | $5.1m | 0.0% |
| Boxer Capital Management, LLC | 275,000 | $5.1m | 0.4% |