| RA CAPITAL MANAGEMENT, L.P. | 3,998,333 | $18.2m | 0.2% |
| BVF INC/IL | 3,235,778 | $14.8m | 0.4% |
| ACORN CAPITAL ADVISORS, LLC | 2,839,674 | $12.9m | 3.5% |
| StepStone Group LP | 2,660,612 | $12.1m | 0.6% |
| ADAR1 Capital Management, LLC | 2,238,684 | $10.2m | 0.5% |
| Vivo Capital, LLC | 1,927,710 | $8.8m | 0.8% |
| Vestal Point Capital, LP | 1,825,699 | $8.3m | 0.2% |
| BlackRock, Inc. | 1,499,845 | $6.8m | 0.0% |
| Trails Edge Capital Partners, LP | 1,438,456 | $6.6m | 1.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,437,039 | $6.6m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,204,819 | $5.5m | 0.0% |
| CITADEL ADVISORS LLC | 1,187,047 | $5.4m | 0.0% |
| Sio Capital Management, LLC | 1,078,965 | $4.9m | 0.8% |
| Prosight Management, LP | 978,992 | $4.5m | 0.8% |
| Logos Global Management LP | 963,855 | $4.4m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 724,438 | $3.3m | 0.0% |
| NEA Management Company, LLC | 478,548 | $2.2m | 0.1% |
| STATE STREET CORP | 463,662 | $2.1m | 0.0% |
| Ensign Peak Advisors, Inc | 431,631 | $2.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 358,738 | $1.6m | 0.0% |
| Sofinnova Investments, Inc. | 321,692 | $1.5m | 0.1% |
| Carlyle Group Inc. | 269,895 | $1.2m | 0.0% |
| Affinity Asset Advisors, LLC | 240,963 | $1.1m | 0.0% |
| DV EQUITIES, LLC | 240,963 | $1.1m | 0.2% |
| Seven Fleet Capital Management LP | 240,963 | $1.1m | 0.2% |