| FMR LLC | 2,742,887 | $11.8m | 0.0% |
| BML Capital Management, LLC | 2,519,701 | $10.9m | 6.2% |
| AQR CAPITAL MANAGEMENT LLC | 998,961 | $4.3m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 833,333 | $3.6m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 780,134 | $3.4m | 0.0% |
| Assenagon Asset Management S.A. | 678,876 | $2.9m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 665,847 | $2.9m | 0.0% |
| PFM Health Sciences, LP | 582,122 | $2.5m | 0.2% |
| Ensign Peak Advisors, Inc | 434,341 | $1.9m | 0.0% |
| BlackRock, Inc. | 418,211 | $1.8m | 0.0% |
| Peapod Lane Capital LLC | 331,951 | $1.4m | 1.0% |
| MARSHALL WACE, LLP | 211,993 | $915,809 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 204,652 | $884,538 | 0.0% |
| Stratos Wealth Partners, LTD. | 200,546 | $866,359 | 0.0% |
| UBS Group AG | 190,289 | $822,048 | 0.0% |
| MORGAN STANLEY | 181,983 | $786,166 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 181,794 | $785,350 | 0.0% |
| GOLDMAN SACHS GROUP INC | 173,460 | $749,348 | 0.0% |
| JANE STREET GROUP, LLC | 139,197 | $601,331 | 0.0% |
| XTX Topco Ltd | 124,690 | $538,661 | 0.0% |
| Catalio Capital Management, LP | 118,279 | $510,965 | 0.1% |
| VANGUARD FIDUCIARY TRUST CO | 114,912 | $496,420 | 0.0% |
| GMT Capital Corp | 98,108 | $423,827 | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 90,698 | $391,828 | 0.0% |
| PURA VIDA INVESTMENTS, LLC | 83,333 | $359,999 | 1.0% |