| BAKER BROS. ADVISORS LP | 8,801,567 | $2.5bn | 12.6% |
| PRIMECAP MANAGEMENT CO/CA/ | 5,007,931 | $1.4bn | 0.8% |
| Capital International Investors | 4,210,221 | $1.2bn | 0.2% |
| FMR LLC | 2,478,527 | $706.3m | 0.0% |
| Capital World Investors | 2,249,582 | $641.1m | 0.1% |
| CITADEL ADVISORS LLC | 1,425,517 | $406.2m | 0.0% |
| Temasek Holdings (Private) Ltd | 845,729 | $241.0m | 0.6% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 758,752 | $216.2m | 0.0% |
| BlackRock, Inc. | 694,618 | $197.9m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 543,323 | $154.8m | 0.1% |
| MORGAN STANLEY | 497,437 | $141.8m | 0.0% |
| Siren, L.L.C. | 465,000 | $132.5m | 2.7% |
| BANK OF AMERICA CORP /DE/ | 439,336 | $125.2m | 0.0% |
| Baird Financial Group, Inc. | 368,978 | $105.1m | 0.1% |
| Man Group plc | 307,463 | $87.6m | 0.1% |
| Capital International, Inc./CA/ | 305,477 | $87.1m | 0.6% |
| Candriam S.C.A. | 289,735 | $82.5m | 0.4% |
| TWO SIGMA INVESTMENTS, LP | 286,552 | $81.7m | 0.1% |
| UBS Group AG | 258,589 | $73.7m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 249,758 | $71.2m | 0.0% |
| FIRST TRUST ADVISORS LP | 245,823 | $70.1m | 0.0% |
| M&G PLC | 223,445 | $63.7m | 0.3% |
| Nuveen, LLC | 201,062 | $57.3m | 0.0% |
| JPMORGAN CHASE & CO | 188,405 | $54.6m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 185,544 | $52.9m | 0.0% |