| Soleus Capital Management, L.P. | 13,063,687 | $27.3m | 0.9% |
| B Group, Inc. | 11,414,285 | $23.9m | 11.2% |
| AMERIPRISE FINANCIAL INC | 11,081,434 | $23.2m | 0.0% |
| Jupiter Topco LLC | 10,689,452 | $22.4m | 0.0% |
| BlackRock, Inc. | 10,436,760 | $21.8m | 0.0% |
| Octagon Capital Advisors LP | 10,276,317 | $21.5m | 1.9% |
| PERCEPTIVE ADVISORS LLC | 8,425,065 | $17.6m | 0.3% |
| RA CAPITAL MANAGEMENT, L.P. | 7,124,116 | $14.9m | 0.1% |
| FRANKLIN RESOURCES INC | 5,785,189 | $12.1m | 0.0% |
| Point72 Asset Management, L.P. | 5,253,403 | $11.0m | 0.0% |
| Boxer Capital Management, LLC | 4,799,875 | $10.0m | 0.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,500,000 | $9.4m | 0.0% |
| Eversept Partners, LP | 4,182,785 | $8.7m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,760,485 | $7.9m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,703,936 | $7.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,578,020 | $7.5m | 0.0% |
| FEDERATED HERMES, INC. | 3,136,607 | $6.6m | 0.0% |
| Squadron Capital Management LLC | 3,000,000 | $6.3m | 1.9% |
| Propel Bio Management, LLC | 2,582,388 | $5.4m | 2.8% |
| Vestal Point Capital, LP | 2,500,000 | $5.2m | 0.1% |
| STATE STREET CORP | 2,475,648 | $5.2m | 0.0% |
| MORGAN STANLEY | 2,474,069 | $5.2m | 0.0% |
| ORBIMED ADVISORS LLC | 2,333,000 | $4.9m | 0.1% |
| GREAT POINT PARTNERS LLC | 2,284,819 | $4.8m | 0.9% |
| SPHERA FUNDS MANAGEMENT LTD. | 2,257,106 | $4.7m | 0.6% |