| FMR LLC | 20,852,907 | $1.2bn | 0.1% |
| Jupiter Topco LLC | 17,965,847 | $1.0bn | 0.4% |
| T. Rowe Price Investment Management, Inc. | 12,207,450 | $709.6m | 0.5% |
| BlackRock, Inc. | 12,068,129 | $701.5m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 11,474,599 | $667.0m | 5.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 7,001,565 | $407.0m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,593,551 | $383.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,348,679 | $369.0m | 0.0% |
| STATE STREET CORP | 5,351,698 | $311.1m | 0.0% |
| Deep Track Capital, LP | 4,300,000 | $250.0m | 3.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,459,363 | $201.1m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,988,999 | $173.8m | 0.0% |
| Kynam Capital Management, LP | 2,922,335 | $169.9m | 9.4% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,472,428 | $143.7m | 0.5% |
| Caligan Partners LP | 2,188,636 | $127.2m | 6.0% |
| Paradigm Biocapital Advisors LP | 2,127,852 | $123.7m | 2.3% |
| Bellevue Group AG | 1,971,935 | $114.6m | 2.4% |
| D. E. Shaw & Co., Inc. | 1,901,872 | $110.6m | 0.1% |
| MAVERICK CAPITAL LTD | 1,613,242 | $93.8m | 0.8% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,464,812 | $85.1m | 0.0% |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,425,470 | $82.9m | 26.9% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,380,219 | $80.2m | 1.1% |
| GOLDMAN SACHS GROUP INC | 1,350,760 | $78.5m | 0.0% |
| NORTHERN TRUST CORP | 1,280,172 | $74.4m | 0.0% |
| NORGES BANK | 1,245,805 | $72.4m | 0.0% |