| ORBIMED ADVISORS LLC | 13,724,571 | $73.2m | 1.4% |
| BAKER BROS. ADVISORS LP | 10,123,824 | $54.0m | 0.3% |
| RA CAPITAL MANAGEMENT, L.P. | 6,475,882 | $34.5m | 0.3% |
| Soleus Capital Management, L.P. | 3,378,378 | $18.0m | 0.6% |
| Kynam Capital Management, LP | 2,415,087 | $12.9m | 0.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,009,445 | $10.7m | 0.0% |
| BlackRock, Inc. | 1,797,501 | $9.6m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 1,019,832 | $5.4m | 0.7% |
| TWO SIGMA INVESTMENTS, LP | 993,369 | $5.3m | 0.0% |
| ADAR1 Capital Management, LLC | 900,900 | $4.8m | 0.2% |
| MILLENNIUM MANAGEMENT LLC | 844,993 | $4.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 841,862 | $4.5m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 766,095 | $4.1m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 611,359 | $3.3m | 0.0% |
| MORGAN STANLEY | 503,860 | $2.7m | 0.0% |
| STATE STREET CORP | 428,787 | $2.3m | 0.0% |
| UBS Group AG | 318,797 | $1.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 284,886 | $1.5m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 281,200 | $1.5m | 0.0% |
| NORTHERN TRUST CORP | 240,599 | $1.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 193,920 | $1.0m | 0.0% |
| MARSHALL WACE, LLP | 190,692 | $1.0m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 125,606 | $669,480 | 0.0% |
| GOLDMAN SACHS GROUP INC | 120,834 | $644,045 | 0.0% |
| Hillsdale Investment Management Inc. | 81,400 | $433,862 | 0.0% |