| First Eagle Investment Management, LLC | 5,506,330 | $23.8m | 0.0% |
| BlackRock, Inc. | 3,635,411 | $15.7m | 0.0% |
| Blue Water Life Science Advisors, LP | 3,474,202 | $15.0m | 9.5% |
| Portolan Capital Management, LLC | 1,899,308 | $8.2m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,800,644 | $7.8m | 0.0% |
| Lionhunter Capital Management, LLC | 1,500,427 | $6.5m | 2.9% |
| AQR CAPITAL MANAGEMENT LLC | 1,343,005 | $5.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,131,377 | $4.9m | 0.0% |
| AMERIPRISE FINANCIAL INC | 987,424 | $4.3m | 0.0% |
| MARSHALL WACE, LLP | 973,872 | $4.2m | 0.0% |
| STATE STREET CORP | 932,307 | $4.0m | 0.0% |
| Tikvah Management LLC | 571,555 | $2.5m | 0.8% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 489,566 | $2.1m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 487,600 | $2.1m | 0.0% |
| MORGAN STANLEY | 447,688 | $1.9m | 0.0% |
| JANE STREET GROUP, LLC | 419,050 | $1.8m | 0.0% |
| GSA CAPITAL PARTNERS LLP | 410,252 | $1.8m | 0.1% |
| TUDOR INVESTMENT CORP ET AL | 400,402 | $1.7m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 397,833 | $1.7m | 0.0% |
| NORTHERN TRUST CORP | 337,227 | $1.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 310,701 | $1.3m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 288,311 | $1.2m | 0.0% |
| UBS Group AG | 281,978 | $1.2m | 0.0% |
| Nuveen, LLC | 232,592 | $1.0m | 0.0% |
| CITADEL ADVISORS LLC | 229,736 | $992,460 | 0.0% |