| ORBIMED ADVISORS LLC | 4,127,987 | $52.6m | 1.0% |
| Boxer Capital Management, LLC | 3,149,310 | $40.1m | 3.0% |
| Atlas Venture Life Science Advisors, LLC | 2,717,106 | $34.6m | 3.9% |
| BVF INC/IL | 2,350,000 | $29.9m | 0.8% |
| RA CAPITAL MANAGEMENT, L.P. | 2,332,457 | $29.7m | 0.3% |
| Point72 Asset Management, L.P. | 1,173,396 | $14.9m | 0.0% |
| Opaleye Management Inc. | 931,000 | $11.9m | 1.1% |
| Logos Global Management LP | 800,000 | $10.2m | 0.4% |
| SummitTX Capital, L.P. | 733,774 | $9.3m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 518,803 | $6.6m | 0.0% |
| Ikarian Capital, LLC | 430,000 | $5.5m | 0.6% |
| Woodline Partners LP | 286,212 | $3.6m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 272,752 | $3.5m | 0.0% |
| Sanofi | 244,083 | $3.1m | 0.6% |
| ACADIAN ASSET MANAGEMENT LLC | 218,234 | $2.8m | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 216,171 | $2.8m | 0.8% |
| RENAISSANCE TECHNOLOGIES LLC | 179,600 | $2.3m | 0.0% |
| JANE STREET GROUP, LLC | 162,747 | $2.1m | 0.0% |
| MONIMUS CAPITAL MANAGEMENT, LP | 132,036 | $1.7m | 0.4% |
| BOOTHBAY FUND MANAGEMENT, LLC | 130,427 | $1.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 122,690 | $1.6m | 0.0% |
| CITADEL ADVISORS LLC | 120,663 | $1.5m | 0.0% |
| BlackRock, Inc. | 118,507 | $1.5m | 0.0% |
| MARSHALL WACE, LLP | 67,045 | $854,153 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 66,217 | $843,605 | 0.0% |