| SAMSARA BIOCAPITAL, LLC | 10,369,159 | $7.9m | 0.6% |
| RA CAPITAL MANAGEMENT, L.P. | 8,500,000 | $6.5m | 0.1% |
| AWM Investment Company, Inc. | 7,500,000 | $5.7m | 0.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,562,985 | $3.5m | 0.0% |
| Longaeva Partners L.P. | 2,329,459 | $1.8m | 0.0% |
| Polar Asset Management Partners Inc. | 2,318,542 | $1.8m | 0.0% |
| Siren, L.L.C. | 2,000,000 | $1.5m | 0.0% |
| HEIGHTS CAPITAL MANAGEMENT, INC | 934,580 | $710,655 | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 890,618 | $677,575 | 0.0% |
| CITADEL ADVISORS LLC | 641,995 | $488,173 | 0.0% |
| MARSHALL WACE, LLP | 586,265 | $445,561 | 0.0% |
| Nan Fung Group Holdings Ltd | 493,584 | $375,321 | 0.3% |
| JANE STREET GROUP, LLC | 485,899 | $369,478 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 458,126 | $348,176 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 430,737 | $327,532 | 0.0% |
| STATE STREET CORP | 373,142 | $283,737 | 0.0% |
| BlackRock, Inc. | 342,113 | $260,142 | 0.0% |
| UNITED SERVICES AUTOMOBILE ASSOCIATION | 302,743 | $230,206 | 0.0% |
| UBS Group AG | 297,270 | $225,926 | 0.0% |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 282,340 | $214,691 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 249,716 | $190,000 | 0.0% |
| NORTHERN TRUST CORP | 170,471 | $129,626 | 0.0% |
| CWA Asset Management Group, LLC | 150,000 | $114,060 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 114,500 | $87,066 | 0.0% |
| KING LUTHER CAPITAL MANAGEMENT CORP | 58,000 | $44,103 | 0.0% |