| GILEAD SCIENCES, INC. | 31,424,760 | $968.8m | 58.8% |
| BlackRock, Inc. | 16,416,249 | $506.1m | 0.0% |
| STATE STREET CORP | 6,029,484 | $185.9m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 5,895,448 | $181.8m | 0.0% |
| MONTANOVA CAPITAL, LLC | 4,776,423 | $147.3m | 2.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,475,528 | $138.0m | 0.0% |
| FMR LLC | 4,049,757 | $124.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,888,346 | $119.9m | 0.0% |
| CITADEL ADVISORS LLC | 3,135,057 | $96.7m | 0.0% |
| Woodline Partners LP | 3,007,798 | $92.7m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,448,749 | $75.5m | 0.0% |
| Siren, L.L.C. | 2,420,430 | $74.6m | 1.5% |
| Fisher Asset Management, LLC | 2,139,396 | $66.0m | 0.0% |
| MARSHALL WACE, LLP | 1,945,088 | $60.0m | 0.0% |
| SAMLYN CAPITAL, LLC | 1,547,182 | $47.7m | 0.8% |
| DIMENSIONAL FUND ADVISORS LP | 1,434,320 | $44.2m | 0.0% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,419,533 | $43.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,387,566 | $42.8m | 0.0% |
| Soleus Capital Management, L.P. | 1,168,738 | $36.0m | 1.2% |
| Sofinnova Investments, Inc. | 945,690 | $29.2m | 1.5% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 941,756 | $29.0m | 0.0% |
| NORTHERN TRUST CORP | 932,523 | $28.7m | 0.0% |
| Parkman Healthcare Partners LLC | 919,266 | $28.3m | 2.9% |
| Invesco Ltd. | 845,233 | $26.1m | 0.0% |
| BAKER BROS. ADVISORS LP | 844,816 | $26.0m | 0.1% |