| BlackRock, Inc. | 13,695,790 | $2.6bn | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 13,550,796 | $2.5bn | 11.7% |
| FMR LLC | 12,200,422 | $2.3bn | 0.1% |
| BAKER BROS. ADVISORS LP | 11,443,357 | $2.1bn | 10.7% |
| Darwin Global Management, Ltd. | 10,629,822 | $2.0bn | 54.5% |
| Jupiter Topco LLC | 10,736,145 | $2.0bn | 0.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 9,088,661 | $1.7bn | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 8,294,855 | $1.6bn | 0.1% |
| Nextech Invest Ltd. | 7,601,087 | $1.4bn | 67.6% |
| Paradigm Biocapital Advisors LP | 6,361,323 | $1.2bn | 22.3% |
| UBS Group AG | 5,448,364 | $1.0bn | 0.1% |
| STATE STREET CORP | 4,897,051 | $917.1m | 0.0% |
| Capital World Investors | 4,008,244 | $750.7m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,942,676 | $736.8m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,843,415 | $719.8m | 0.1% |
| JPMORGAN CHASE & CO | 3,298,066 | $636.9m | 0.0% |
| BVF INC/IL | 2,965,160 | $555.3m | 14.2% |
| Alphabet Inc. | 2,946,619 | $551.8m | 0.6% |
| Casdin Capital, LLC | 2,577,333 | $482.7m | 24.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,392,000 | $448.0m | 4.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,390,303 | $447.7m | 0.0% |
| Avoro Capital Advisors LLC | 2,297,000 | $430.2m | 3.9% |
| NORGES BANK | 2,157,479 | $404.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,133,101 | $399.5m | 0.0% |
| Nearwater Capital Markets, Ltd | 2,097,000 | $392.7m | 6.8% |