| Caligan Partners LP | 7,967,207 | $31.1m | 1.5% |
| Vivo Capital, LLC | 7,299,909 | $28.5m | 2.6% |
| PERCEPTIVE ADVISORS LLC | 6,627,501 | $25.8m | 0.4% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,405,553 | $25.0m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 4,401,500 | $17.2m | 0.1% |
| Balyasny Asset Management L.P. | 3,760,439 | $14.7m | 0.0% |
| BlackRock, Inc. | 3,066,016 | $12.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,972,929 | $11.6m | 0.0% |
| Commodore Capital LP | 2,870,000 | $11.2m | 0.7% |
| MILLENNIUM MANAGEMENT LLC | 2,749,087 | $10.7m | 0.0% |
| Spruce Street Capital LP | 2,198,502 | $8.6m | 1.7% |
| Sessa Capital IM, L.P. | 2,198,457 | $8.6m | 0.1% |
| Affinity Asset Advisors, LLC | 1,525,000 | $5.9m | 0.3% |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,481,660 | $5.8m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,277,185 | $5.0m | 0.0% |
| Woodline Partners LP | 1,180,355 | $4.6m | 0.0% |
| Ensign Peak Advisors, Inc | 1,172,641 | $4.6m | 0.0% |
| Propel Bio Management, LLC | 1,076,578 | $4.2m | 2.2% |
| Soleus Capital Management, L.P. | 900,000 | $3.5m | 0.1% |
| Seven Fleet Capital Management LP | 736,077 | $2.9m | 0.5% |
| AMERIPRISE FINANCIAL INC | 611,019 | $2.4m | 0.0% |
| STATE STREET CORP | 530,831 | $2.1m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 438,515 | $1.7m | 0.0% |
| DV EQUITIES, LLC | 400,000 | $1.6m | 0.2% |
| AWM Investment Company, Inc. | 375,000 | $1.5m | 0.1% |