| BAKER BROS. ADVISORS LP | 5,498,170 | $10.0m | 0.1% |
| Whetstone Capital Advisors, LLC | 3,306,889 | $6.0m | 1.6% |
| Aberdeen Group plc | 2,753,525 | $5.0m | 0.0% |
| Vivo Capital, LLC | 1,650,440 | $3.0m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,297,792 | $2.4m | 0.0% |
| CAPTRUST FINANCIAL ADVISORS | 535,755 | $975,074 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 348,967 | $635,473 | 0.0% |
| BlackRock, Inc. | 221,369 | $402,891 | 0.0% |
| AWM Investment Company, Inc. | 207,382 | $377,435 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 170,908 | $311,053 | 0.0% |
| STATE STREET CORP | 124,792 | $227,121 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 73,986 | $134,655 | 0.0% |
| Perigon Wealth Management, LLC | 72,685 | $132,287 | 0.0% |
| NORTHERN TRUST CORP | 68,595 | $124,843 | 0.0% |
| Bank of New York Mellon Corp | 60,927 | $110,887 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 55,705 | $101,383 | 0.0% |
| Requisite Capital Management, LLC | 55,648 | $101,279 | 0.0% |
| MORGAN STANLEY | 50,972 | $92,769 | 0.0% |
| Qube Research & Technologies Ltd | 50,871 | $92,585 | 0.0% |
| Ballentine Partners, LLC | 49,664 | $90,388 | 0.0% |
| Twelve Points Wealth Management LLC | 43,388 | $78,966 | 0.0% |
| HighTower Advisors, LLC | 42,234 | $76,866 | 0.0% |
| CITADEL ADVISORS LLC | 41,411 | $75,368 | 0.0% |
| Catalyst Funds Management Pty Ltd | 38,890 | $70,780 | 0.0% |
| GOLDMAN SACHS GROUP INC | 32,541 | $59,225 | 0.0% |