| BlackRock, Inc. | 6,575,788 | $50.8m | 0.0% |
| Balyasny Asset Management L.P. | 3,626,113 | $28.0m | 0.0% |
| Woodline Partners LP | 3,000,652 | $23.2m | 0.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,927,698 | $22.6m | 2.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,566,272 | $19.8m | 0.0% |
| BVF INC/IL | 2,500,000 | $19.3m | 0.5% |
| Caligan Partners LP | 2,500,000 | $19.3m | 0.9% |
| Affinity Asset Advisors, LLC | 2,497,864 | $19.3m | 0.9% |
| FEDERATED HERMES, INC. | 2,086,715 | $16.1m | 0.0% |
| GREAT POINT PARTNERS LLC | 2,029,933 | $15.7m | 3.0% |
| STATE STREET CORP | 1,995,092 | $15.4m | 0.0% |
| Saturn V Capital Management LP | 1,479,918 | $11.4m | 1.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,444,019 | $11.2m | 0.0% |
| Blue Owl Capital Holdings LP | 1,260,544 | $9.7m | 1.5% |
| BAKER BROS. ADVISORS LP | 952,996 | $7.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 937,025 | $7.2m | 0.0% |
| Aberdeen Group plc | 847,700 | $6.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 759,086 | $5.9m | 0.0% |
| HHLR ADVISORS, LTD. | 724,800 | $5.6m | 0.7% |
| AMERIPRISE FINANCIAL INC | 581,217 | $4.5m | 0.0% |
| Vestal Point Capital, LP | 535,452 | $4.1m | 0.1% |
| NORTHERN TRUST CORP | 468,385 | $3.6m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 464,095 | $3.6m | 0.0% |
| ADAR1 Capital Management, LLC | 437,500 | $3.4m | 0.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 415,000 | $3.2m | 0.0% |