| RA CAPITAL MANAGEMENT, L.P. | 8,021,117 | $178.6m | 1.6% |
| NEA Management Company, LLC | 7,392,301 | $164.6m | 10.4% |
| Sands Capital Alternatives, LLC | 2,500,012 | $55.7m | 9.1% |
| SAMSARA BIOCAPITAL, LLC | 2,109,953 | $47.0m | 3.9% |
| BlackRock, Inc. | 711,712 | $15.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 674,143 | $15.0m | 0.0% |
| Vestal Point Capital, LP | 670,000 | $14.9m | 0.3% |
| JPMORGAN CHASE & CO | 629,739 | $13.6m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 550,000 | $12.2m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 507,257 | $11.3m | 0.0% |
| Aberdeen Group plc | 493,076 | $11.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 434,423 | $9.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 277,325 | $6.2m | 0.0% |
| FRANKLIN RESOURCES INC | 233,412 | $5.2m | 0.0% |
| Affinity Asset Advisors, LLC | 131,586 | $2.9m | 0.1% |
| STATE STREET CORP | 117,561 | $2.6m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 85,681 | $1.9m | 0.0% |
| NORTHERN TRUST CORP | 82,451 | $1.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 75,812 | $1.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 68,498 | $1.5m | 0.0% |
| Alyeska Investment Group, L.P. | 57,000 | $1.3m | 0.0% |
| TD Asset Management Inc | 47,580 | $1.1m | 0.0% |
| AMERIPRISE FINANCIAL INC | 45,668 | $1.0m | 0.0% |
| ALPS ADVISORS INC | 33,932 | $755,326 | 0.0% |
| Bank of New York Mellon Corp | 23,944 | $532,993 | 0.0% |