| BlackRock, Inc. | 9,020,006 | $197.2m | 0.0% |
| Kynam Capital Management, LP | 8,050,959 | $176.0m | 9.7% |
| GOLDMAN SACHS GROUP INC | 5,861,265 | $128.1m | 0.0% |
| STATE STREET CORP | 5,658,424 | $123.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 4,045,094 | $88.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,927,892 | $85.9m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,779,900 | $82.6m | 0.9% |
| Eversept Partners, LP | 2,798,210 | $61.2m | 3.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,584,136 | $56.5m | 0.0% |
| Hood River Capital Management LLC | 2,564,279 | $56.1m | 0.4% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,500,000 | $54.6m | 5.6% |
| FRANKLIN RESOURCES INC | 2,286,499 | $50.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,053,960 | $44.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,921,796 | $42.0m | 0.0% |
| UBS Group AG | 1,893,750 | $41.4m | 0.0% |
| Elmind Capital, LP | 1,855,000 | $40.6m | 10.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,790,173 | $39.1m | 0.0% |
| Candriam S.C.A. | 1,696,040 | $37.0m | 0.2% |
| Soleus Capital Management, L.P. | 1,628,039 | $35.6m | 1.2% |
| TWO SIGMA INVESTMENTS, LP | 1,578,125 | $34.5m | 0.0% |
| ORBIMED ADVISORS LLC | 1,542,000 | $33.7m | 0.6% |
| Nuveen, LLC | 1,364,575 | $29.8m | 0.0% |
| MPM BIOIMPACT LLC | 1,333,523 | $29.2m | 1.8% |
| Aisling Capital Management LP | 1,316,806 | $28.8m | 6.1% |
| Woodline Partners LP | 1,250,760 | $27.3m | 0.1% |