| AIGH Capital Management LLC | 250,000 | $13.5m | 0.9% |
| ORBIMED ADVISORS LLC | 200,000 | $10.8m | 0.2% |
| BlackRock, Inc. | 187,836 | $10.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 160,981 | $8.7m | 0.0% |
| Ikarian Capital, LLC | 121,356 | $6.6m | 0.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 119,331 | $6.4m | 0.0% |
| Alyeska Investment Group, L.P. | 81,671 | $4.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 70,548 | $3.8m | 0.0% |
| ADAR1 Capital Management, LLC | 67,717 | $3.7m | 0.2% |
| Cable Car Capital, LP | 60,000 | $3.2m | 0.1% |
| CITADEL ADVISORS LLC | 51,905 | $2.8m | 0.0% |
| STATE STREET CORP | 50,450 | $2.7m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 42,080 | $2.3m | 0.0% |
| STEMPOINT CAPITAL LP | 41,388 | $2.2m | 0.4% |
| Eversept Partners, LP | 40,000 | $2.2m | 0.1% |
| Carlyle Group Inc. | 38,620 | $2.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 32,348 | $1.7m | 0.0% |
| Affinity Asset Advisors, LLC | 30,000 | $1.6m | 0.1% |
| DIADEMA PARTNERS LP | 30,000 | $1.6m | 0.2% |
| Stonepine Capital Management, LLC | 28,795 | $1.6m | 0.4% |
| Point72 Asset Management, L.P. | 28,278 | $1.5m | 0.0% |
| Quinn Opportunity Partners LLC | 26,810 | $1.4m | 0.1% |
| UBS Group AG | 23,381 | $1.3m | 0.0% |
| ExodusPoint Capital Management, LP | 22,000 | $1.2m | 0.0% |
| NORTHERN TRUST CORP | 21,083 | $1.1m | 0.0% |