| ARCH Venture Management, LLC | 6,294,951 | $136.6m | 12.4% |
| GENERAL ATLANTIC, L.P. | 6,101,582 | $132.5m | 4.6% |
| Sofinnova Investments, Inc. | 3,564,871 | $77.4m | 4.0% |
| GOLDMAN SACHS GROUP INC | 2,178,642 | $47.3m | 0.0% |
| TRV GP VI, LLC | 2,061,222 | $44.8m | 19.3% |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,975,791 | $42.9m | 0.0% |
| JPMORGAN CHASE & CO | 1,815,845 | $40.9m | 0.0% |
| Foresite Capital Management VI LLC | 1,779,521 | $38.7m | 6.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,308,604 | $28.4m | 0.0% |
| FMR LLC | 1,185,100 | $25.7m | 0.0% |
| Bellevue Group AG | 1,100,000 | $23.9m | 0.5% |
| Siren, L.L.C. | 1,095,316 | $23.8m | 0.5% |
| JENNISON ASSOCIATES LLC | 1,079,669 | $23.5m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 700,000 | $15.2m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 599,217 | $13.0m | 0.0% |
| Woodline Partners LP | 586,345 | $12.7m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 500,000 | $10.9m | 0.2% |
| BRAIDWELL LP | 500,000 | $10.9m | 0.4% |
| PRINCIPAL FINANCIAL GROUP INC | 414,672 | $9.0m | 0.0% |
| Aberdeen Group plc | 310,355 | $6.7m | 0.0% |
| UBS Group AG | 279,184 | $6.1m | 0.0% |
| BlackRock, Inc. | 229,863 | $5.0m | 0.0% |
| SEVEN GRAND MANAGERS, LLC | 225,000 | $4.9m | 0.2% |
| CITADEL ADVISORS LLC | 191,144 | $4.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 175,866 | $3.8m | 0.0% |