| TCG Crossover Management, LLC | 1,473,101 | $38.2m | 0.9% |
| Boxer Capital Management, LLC | 1,105,683 | $27.0m | 2.0% |
| Kalehua Capital Management LLC | 770,356 | $20.0m | 6.4% |
| MILLENNIUM MANAGEMENT LLC | 683,079 | $17.7m | 0.0% |
| Point72 Asset Management, L.P. | 664,272 | $17.2m | 0.0% |
| Venrock Adviser, LLC | 632,931 | $16.4m | 0.5% |
| STEMPOINT CAPITAL LP | 602,798 | $13.8m | 2.4% |
| PERCEPTIVE ADVISORS LLC | 503,985 | $13.1m | 0.2% |
| Spruce Street Capital LP | 432,040 | $11.2m | 2.2% |
| BlackRock, Inc. | 394,864 | $10.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 392,550 | $10.2m | 0.0% |
| BRAIDWELL LP | 390,753 | $10.1m | 0.4% |
| Vestal Point Capital, LP | 304,669 | $7.9m | 0.2% |
| 5AM Venture Management, LLC | 271,250 | $7.0m | 2.4% |
| Vivo Capital, LLC | 260,000 | $6.7m | 0.6% |
| Balyasny Asset Management L.P. | 205,032 | $5.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 201,652 | $5.2m | 0.0% |
| ACUTA CAPITAL PARTNERS, LLC | 173,395 | $4.5m | 3.1% |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | $3.5m | 0.1% |
| STATE STREET CORP | 133,084 | $3.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 113,531 | $2.9m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | $2.3m | 0.0% |
| Euclidean Capital LLC | 87,696 | $2.3m | 0.5% |
| TWO SIGMA INVESTMENTS, LP | 71,119 | $1.8m | 0.0% |
| NORTHERN TRUST CORP | 63,609 | $1.7m | 0.0% |