| PERCEPTIVE ADVISORS LLC | 1,304,846 | $43.3m | 0.7% |
| BVF INC/IL | 1,251,788 | $41.6m | 1.1% |
| Affinity Asset Advisors, LLC | 1,172,487 | $38.9m | 1.8% |
| BlackRock, Inc. | 1,122,655 | $37.3m | 0.0% |
| SAMSARA BIOCAPITAL, LLC | 1,062,872 | $35.3m | 2.9% |
| Kynam Capital Management, LP | 872,558 | $29.0m | 1.6% |
| ORBIMED ADVISORS LLC | 743,944 | $24.7m | 0.5% |
| Balyasny Asset Management L.P. | 711,162 | $23.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 694,219 | $23.0m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 585,262 | $19.4m | 0.3% |
| Velan Capital Investment Management LP | 512,160 | $17.0m | 10.4% |
| Woodline Partners LP | 458,029 | $15.2m | 0.0% |
| ADAR1 Capital Management, LLC | 404,014 | $13.4m | 0.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 389,692 | $12.9m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 373,839 | $12.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 365,972 | $12.2m | 0.0% |
| STATE STREET CORP | 305,979 | $10.2m | 0.0% |
| Merck & Co., Inc. | 272,351 | $9.0m | 1.7% |
| ACUTA CAPITAL PARTNERS, LLC | 270,251 | $9.0m | 6.3% |
| AMERIPRISE FINANCIAL INC | 244,669 | $8.1m | 0.0% |
| Point72 Asset Management, L.P. | 237,827 | $7.9m | 0.0% |
| KVP Capital Advisors, LP | 226,575 | $7.5m | 5.5% |
| UBS Group AG | 208,512 | $6.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 201,688 | $6.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 197,562 | $6.6m | 0.0% |