| FMR LLC | 13,026,187 | $1.2bn | 0.1% |
| BlackRock, Inc. | 6,506,605 | $577.7m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 4,319,496 | $383.5m | 5.8% |
| RTW INVESTMENTS, LP | 4,251,996 | $377.5m | 3.2% |
| Paradigm Biocapital Advisors LP | 3,840,778 | $341.0m | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,448,681 | $306.2m | 0.0% |
| STATE STREET CORP | 3,057,416 | $271.4m | 0.0% |
| Venrock Adviser, LLC | 2,985,448 | $265.0m | 8.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,960,855 | $262.9m | 0.0% |
| Driehaus Capital Management LLC | 2,799,166 | $248.5m | 1.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,562,265 | $239.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,330,098 | $206.9m | 0.0% |
| Capital World Investors | 2,315,553 | $205.6m | 0.0% |
| Jupiter Topco LLC | 2,206,936 | $195.9m | 0.1% |
| TCG Crossover Management, LLC | 1,900,582 | $168.7m | 4.1% |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $168.0m | 7.6% |
| BANK OF AMERICA CORP /DE/ | 1,777,854 | $157.8m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,722,300 | $152.9m | 0.2% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,581,505 | $140.4m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,478,059 | $131.2m | 0.0% |
| FRANKLIN RESOURCES INC | 1,472,943 | $130.8m | 0.0% |
| Remedium Capital Partners, LLC | 1,464,169 | $130.0m | 28.8% |
| Affinity Asset Advisors, LLC | 1,279,134 | $113.6m | 5.1% |
| JPMORGAN CHASE & CO | 1,093,026 | $98.9m | 0.0% |
| Holocene Advisors, LP | 1,015,170 | $90.1m | 0.2% |