| Lynx1 Capital Management LP | 8,019,148 | $7.9m | 0.9% |
| BVF INC/IL | 5,564,290 | $5.5m | 0.1% |
| BAKER BROS. ADVISORS LP | 2,784,792 | $2.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,158,831 | $2.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,949,604 | $1.9m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,326,799 | $1.3m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,305,840 | $1.3m | 0.0% |
| Deer Management Co. LLC | 1,245,504 | $1.2m | 0.2% |
| MILLENNIUM MANAGEMENT LLC | 1,163,611 | $1.1m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,049,806 | $1.0m | 0.0% |
| CITADEL ADVISORS LLC | 1,009,107 | $989,026 | 0.0% |
| BlackRock, Inc. | 994,654 | $974,860 | 0.0% |
| Kalehua Capital Management LLC | 909,752 | $891,648 | 0.3% |
| BOOTHBAY FUND MANAGEMENT, LLC | 772,241 | $756,873 | 0.0% |
| MARSHALL WACE, LLP | 687,364 | $673,616 | 0.0% |
| DC Funds, LP | 630,000 | $617,463 | 49.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 584,811 | $573,401 | 0.0% |
| D. E. Shaw & Co., Inc. | 548,402 | $537,489 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 548,087 | $537,000 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 363,954 | $356,675 | 0.0% |
| JANE STREET GROUP, LLC | 241,493 | $236,687 | 0.0% |
| Verdad Advisers, LP | 232,759 | $228,127 | 0.2% |
| STATE STREET CORP | 207,313 | $203,187 | 0.0% |
| MIZUHO SECURITIES USA LLC | 205,600 | $201,509 | 0.0% |
| MORGAN STANLEY | 197,891 | $193,952 | 0.0% |