| FMR LLC | 3,942,373 | $57.4m | 0.0% |
| Vivo Capital, LLC | 2,500,000 | $36.4m | 3.3% |
| BlackRock, Inc. | 1,727,988 | $25.1m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,700,000 | $24.7m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,147,121 | $16.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 876,230 | $12.7m | 0.0% |
| Ikarian Capital, LLC | 787,600 | $11.5m | 1.2% |
| Candriam S.C.A. | 749,588 | $10.9m | 0.0% |
| CITADEL ADVISORS LLC | 728,561 | $10.6m | 0.0% |
| RTW INVESTMENTS, LP | 696,570 | $10.1m | 0.1% |
| Stonepine Capital Management, LLC | 660,000 | $9.6m | 2.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 639,537 | $9.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 607,660 | $8.8m | 0.0% |
| MARSHALL WACE, LLP | 585,578 | $8.5m | 0.0% |
| BRAIDWELL LP | 584,412 | $8.5m | 0.3% |
| Point72 Asset Management, L.P. | 556,761 | $8.1m | 0.0% |
| Velan Capital Investment Management LP | 549,985 | $8.0m | 4.9% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 540,126 | $7.9m | 0.0% |
| Woodline Partners LP | 531,254 | $7.7m | 0.0% |
| STATE STREET CORP | 510,814 | $7.4m | 0.0% |
| Sofinnova Investments, Inc. | 500,039 | $7.3m | 0.4% |
| Jupiter Topco LLC | 451,226 | $6.6m | 0.0% |
| MORGAN STANLEY | 432,220 | $6.3m | 0.0% |
| Qube Research & Technologies Ltd | 429,893 | $6.3m | 0.0% |
| Siren, L.L.C. | 427,141 | $6.2m | 0.1% |