| FMR LLC | 17,629,266 | $675.9m | 0.0% |
| BlackRock, Inc. | 10,804,070 | $414.2m | 0.0% |
| ARK Investment Management LLC | 10,003,057 | $383.5m | 2.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,982,492 | $267.7m | 0.0% |
| Quantinno Capital Management LP | 5,469,698 | $209.7m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,082,594 | $194.9m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,539,007 | $174.0m | 0.0% |
| Sumitomo Mitsui Trust Group, Inc. | 4,194,627 | $160.8m | 0.1% |
| Amova Asset Management Americas, Inc. | 4,192,517 | $160.7m | 2.1% |
| MORGAN STANLEY | 3,351,911 | $128.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,148,859 | $120.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,082,790 | $118.2m | 0.0% |
| STATE STREET CORP | 2,801,437 | $107.4m | 0.0% |
| CITADEL ADVISORS LLC | 2,779,213 | $106.6m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,225,284 | $85.3m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,019,883 | $77.4m | 0.3% |
| AQR CAPITAL MANAGEMENT LLC | 2,026,464 | $74.7m | 0.0% |
| Point72 Asset Management, L.P. | 1,852,776 | $71.0m | 0.1% |
| Capital World Investors | 1,493,031 | $57.2m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 1,266,954 | $48.6m | 0.0% |
| NORTHERN TRUST CORP | 1,144,027 | $43.9m | 0.0% |
| Nuveen, LLC | 1,124,633 | $43.1m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,087,150 | $41.7m | 0.0% |
| Casdin Capital, LLC | 1,050,000 | $40.3m | 2.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 988,320 | $37.9m | 0.1% |