| BlackRock, Inc. | 20,678,283 | $210.7m | 0.0% |
| ARCH Venture Management, LLC | 12,694,163 | $129.4m | 11.8% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 11,495,215 | $117.1m | 0.0% |
| SB INVESTMENT ADVISERS (UK) LTD | 10,948,093 | $111.6m | 1.5% |
| STATE STREET CORP | 9,964,151 | $101.5m | 0.0% |
| GSK plc | 8,550,954 | $87.1m | 14.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,388,775 | $65.1m | 0.0% |
| Point72 Asset Management, L.P. | 5,666,821 | $57.7m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,348,366 | $34.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 3,119,421 | $31.8m | 0.0% |
| ADAR1 Capital Management, LLC | 2,456,677 | $25.0m | 1.1% |
| GOLDMAN SACHS GROUP INC | 2,365,219 | $24.1m | 0.0% |
| FMR LLC | 2,318,294 | $23.6m | 0.0% |
| MORGAN STANLEY | 2,211,077 | $22.5m | 0.0% |
| Nuveen, LLC | 1,982,942 | $20.2m | 0.0% |
| Pictet Asset Management Holding SA | 1,953,316 | $19.9m | 0.0% |
| Boxer Capital Management, LLC | 1,866,000 | $19.0m | 1.4% |
| NORTHERN TRUST CORP | 1,432,165 | $14.6m | 0.0% |
| Hudson Bay Capital Management LP | 1,364,000 | $13.9m | 0.0% |
| GordonMD Global Investments LP | 1,353,552 | $13.8m | 6.7% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,323,185 | $13.5m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,142,539 | $11.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,110,227 | $11.3m | 0.0% |
| Sio Capital Management, LLC | 1,075,274 | $11.0m | 1.8% |
| Savvy Advisors, Inc. | 1,040,665 | $10.6m | 0.2% |