| MORGAN STANLEY | 9,461,279 | $44.2m | 0.0% |
| FMR LLC | 8,321,657 | $38.9m | 0.0% |
| Bain Capital Life Sciences Investors, LLC | 7,967,454 | $37.2m | 2.2% |
| PERCEPTIVE ADVISORS LLC | 7,933,491 | $37.0m | 0.6% |
| Kalehua Capital Management LLC | 7,445,680 | $34.8m | 11.1% |
| Saturn V Capital Management LP | 6,973,343 | $32.6m | 4.7% |
| Empery Asset Management, LP | 6,930,591 | $32.4m | 37.4% |
| Deep Track Capital, LP | 5,878,757 | $27.5m | 0.4% |
| BlackRock, Inc. | 5,554,906 | $25.9m | 0.0% |
| Nantahala Capital Management, LLC | 4,898,936 | $22.9m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,715,859 | $17.4m | 0.0% |
| Rosalind Advisors, Inc. | 3,214,766 | $15.0m | 5.6% |
| BRAIDWELL LP | 2,922,754 | $13.6m | 0.5% |
| Blackstone Inc. | 2,681,922 | $12.5m | 0.0% |
| Trails Edge Capital Partners, LP | 2,571,478 | $12.0m | 1.9% |
| BVF INC/IL | 2,233,742 | $10.4m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,098,047 | $9.8m | 0.0% |
| Venrock Adviser, LLC | 1,934,253 | $9.0m | 0.3% |
| SAMSARA BIOCAPITAL, LLC | 1,395,587 | $6.5m | 0.5% |
| STATE STREET CORP | 1,296,017 | $6.1m | 0.0% |
| Woodline Partners LP | 1,001,095 | $4.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 916,536 | $4.3m | 0.0% |
| NORTHERN TRUST CORP | 652,849 | $3.0m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 572,038 | $2.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 542,128 | $2.5m | 0.0% |