| PRIMECAP MANAGEMENT CO/CA/ | 6,636,057 | $640.5m | 0.4% |
| FMR LLC | 3,918,177 | $378.2m | 0.0% |
| BlackRock, Inc. | 3,838,343 | $370.5m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,151,845 | $208.4m | 2.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,047,813 | $197.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,035,884 | $196.5m | 0.0% |
| Hood River Capital Management LLC | 1,988,360 | $191.9m | 1.4% |
| Driehaus Capital Management LLC | 1,768,213 | $170.7m | 1.0% |
| FIRST TRUST ADVISORS LP | 1,743,499 | $168.3m | 0.1% |
| FULLER & THALER ASSET MANAGEMENT, INC. | 1,430,549 | $138.1m | 0.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,322,581 | $127.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,224,198 | $118.2m | 0.0% |
| STATE STREET CORP | 1,104,198 | $106.6m | 0.0% |
| SIEMENS AG | 1,049,759 | $101.3m | 20.5% |
| BAILLIE GIFFORD & CO | 1,018,568 | $98.3m | 0.1% |
| Durable Capital Partners LP | 1,014,976 | $98.0m | 1.0% |
| GILDER GAGNON HOWE & CO LLC | 857,146 | $82.7m | 0.9% |
| AMERIPRISE FINANCIAL INC | 847,510 | $81.8m | 0.0% |
| Stephens Investment Management Group LLC | 799,180 | $77.1m | 0.8% |
| UBS Group AG | 771,312 | $74.4m | 0.0% |
| Clearbridge Investments, LLC | 742,196 | $71.6m | 0.1% |
| Invesco Ltd. | 729,602 | $70.4m | 0.0% |
| NEXT CENTURY GROWTH INVESTORS LLC | 723,351 | $69.8m | 3.7% |
| JANE STREET GROUP, LLC | 722,361 | $69.7m | 0.0% |
| Allspring Global Investments Holdings, LLC | 643,596 | $61.6m | 0.1% |