| RTW INVESTMENTS, LP | 6,574,032 | $124.9m | 1.1% |
| TCG Crossover Management, LLC | 6,137,627 | $116.6m | 2.8% |
| RA CAPITAL MANAGEMENT, L.P. | 5,743,533 | $109.1m | 0.9% |
| ADAR1 Capital Management, LLC | 3,369,034 | $64.0m | 2.9% |
| FMR LLC | 2,815,214 | $53.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,315,480 | $44.0m | 0.0% |
| Woodline Partners LP | 2,207,293 | $41.9m | 0.1% |
| Frazier Life Sciences Management, L.P. | 1,902,320 | $36.1m | 0.8% |
| BAMCO INC /NY/ | 1,623,694 | $30.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,299,394 | $24.7m | 0.0% |
| CITADEL ADVISORS LLC | 1,284,706 | $24.4m | 0.0% |
| Rock Springs Capital Management LP | 814,707 | $15.5m | 0.8% |
| BlackRock, Inc. | 664,462 | $12.6m | 0.0% |
| C WorldWide Group Holding A/S | 510,000 | $9.7m | 0.2% |
| JANE STREET GROUP, LLC | 476,541 | $9.1m | 0.0% |
| B Group, Inc. | 450,646 | $8.6m | 4.0% |
| Nantahala Capital Management, LLC | 400,000 | $7.6m | 0.1% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 393,167 | $7.2m | 0.0% |
| NAN FUNG TRINITY (HK) LTD | 346,466 | $6.6m | 0.6% |
| Aberdeen Group plc | 311,294 | $5.9m | 0.0% |
| CITIGROUP INC | 300,775 | $5.7m | 0.0% |
| Spruce Street Capital LP | 279,110 | $5.3m | 1.0% |
| AMERIPRISE FINANCIAL INC | 253,171 | $4.8m | 0.0% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 246,982 | $4.7m | 0.0% |
| Hennion & Walsh Asset Management, Inc. | 230,418 | $4.4m | 0.1% |