| TCG Crossover Management, LLC | 10,000,000 | $20.1m | 0.5% |
| Nantahala Capital Management, LLC | 8,636,218 | $17.4m | 0.3% |
| BlackRock, Inc. | 7,847,879 | $15.8m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 4,414,345 | $8.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,009,340 | $8.1m | 0.0% |
| Kynam Capital Management, LP | 3,808,494 | $7.7m | 0.4% |
| Merck & Co., Inc. | 3,545,719 | $7.1m | 1.4% |
| Balyasny Asset Management L.P. | 3,247,426 | $6.5m | 0.0% |
| 683 Capital Management, LLC | 3,200,000 | $6.4m | 0.3% |
| D. E. Shaw & Co., Inc. | 2,959,983 | $5.9m | 0.0% |
| ADAR1 Capital Management, LLC | 2,883,583 | $5.8m | 0.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,820,493 | $5.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,454,271 | $4.9m | 0.0% |
| Spruce Street Capital LP | 2,101,068 | $4.2m | 0.8% |
| MILLENNIUM MANAGEMENT LLC | 1,988,835 | $4.0m | 0.0% |
| Ikarian Capital, LLC | 1,982,606 | $4.0m | 0.4% |
| STATE STREET CORP | 1,879,765 | $3.8m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,765,929 | $3.5m | 0.0% |
| MEDICI CAPITAL LLC | 1,652,520 | $3.3m | 6.5% |
| Affinity Asset Advisors, LLC | 1,510,000 | $3.0m | 0.1% |
| Eversept Partners, LP | 1,423,873 | $2.9m | 0.1% |
| FMR LLC | 1,396,398 | $2.8m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,309,577 | $2.6m | 0.0% |
| Euclidean Capital LLC | 1,307,858 | $2.6m | 0.6% |
| MACKENZIE FINANCIAL CORP | 1,109,770 | $2.2m | 0.0% |