| BlackRock, Inc. | 30,146,963 | $62.7m | 0.0% |
| Pfizer Inc | 22,032,040 | $46.9m | 27.5% |
| Frazier Life Sciences Management, L.P. | 22,446,668 | $46.7m | 1.0% |
| STATE STREET CORP | 19,025,826 | $39.6m | 0.0% |
| TPG GP A, LLC | 18,716,306 | $38.9m | 0.8% |
| Sio Capital Management, LLC | 13,323,431 | $27.7m | 4.6% |
| PRIMECAP MANAGEMENT CO/CA/ | 13,123,440 | $27.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 12,166,636 | $25.3m | 0.0% |
| FMR LLC | 12,009,043 | $25.0m | 0.0% |
| CITADEL ADVISORS LLC | 10,087,770 | $21.0m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 7,784,348 | $16.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 7,049,328 | $14.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 6,148,959 | $12.8m | 0.0% |
| GordonMD Global Investments LP | 5,298,000 | $11.0m | 5.3% |
| MARSHALL WACE, LLP | 5,095,408 | $10.6m | 0.0% |
| Patient Square Capital LP | 5,050,000 | $10.5m | 1.6% |
| Aberdeen Group plc | 5,001,752 | $10.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 4,843,889 | $10.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 4,710,735 | $9.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,639,283 | $9.7m | 0.0% |
| MORGAN STANLEY | 4,509,962 | $9.4m | 0.0% |
| Woodline Partners LP | 4,500,624 | $9.4m | 0.0% |
| Candriam S.C.A. | 4,336,296 | $9.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,212,078 | $8.8m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 3,834,312 | $8.0m | 0.0% |