| EcoR1 Capital, LLC | 7,880,094 | $531.9m | 25.9% |
| BlackRock, Inc. | 1,844,049 | $124.5m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 1,330,879 | $89.8m | 4.1% |
| STATE STREET CORP | 1,286,194 | $86.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 906,233 | $61.2m | 0.0% |
| Affinity Asset Advisors, LLC | 826,109 | $55.8m | 2.5% |
| Sanofi | 821,917 | $55.5m | 10.4% |
| MILLENNIUM MANAGEMENT LLC | 807,316 | $54.5m | 0.0% |
| Woodline Partners LP | 717,014 | $48.4m | 0.1% |
| 683 Capital Management, LLC | 660,000 | $44.6m | 2.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 637,873 | $43.1m | 0.0% |
| Palo Alto Investors LP | 603,489 | $40.7m | 5.6% |
| GOLDMAN SACHS GROUP INC | 584,070 | $39.4m | 0.0% |
| First Light Asset Management, LLC | 582,004 | $39.3m | 2.4% |
| D. E. Shaw & Co., Inc. | 539,666 | $36.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 527,858 | $35.6m | 0.0% |
| Apis Capital Advisors, LLC | 497,000 | $33.5m | 3.3% |
| Sofinnova Investments, Inc. | 493,536 | $33.3m | 1.7% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 488,651 | $33.0m | 0.0% |
| Nuveen, LLC | 420,664 | $28.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 417,812 | $28.2m | 0.0% |
| CITADEL ADVISORS LLC | 394,373 | $26.6m | 0.0% |
| FEDERATED HERMES, INC. | 391,667 | $26.4m | 0.0% |
| Squarepoint Ops LLC | 324,446 | $21.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 262,995 | $17.8m | 0.0% |