| BlackRock, Inc. | 7,609,123 | $63.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,123,399 | $34.3m | 0.0% |
| D. E. Shaw & Co., Inc. | 3,495,153 | $29.0m | 0.0% |
| Pfizer Inc | 3,457,815 | $27.7m | 16.2% |
| ARMISTICE CAPITAL, LLC | 2,796,000 | $23.2m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,714,163 | $22.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,573,447 | $21.4m | 0.0% |
| STATE STREET CORP | 2,196,872 | $18.3m | 0.0% |
| Nextech Invest Ltd. | 1,122,713 | $17.1m | 0.8% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,667,265 | $13.9m | 0.0% |
| Qube Research & Technologies Ltd | 1,592,276 | $13.2m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,412,643 | $11.7m | 0.0% |
| FEDERATED HERMES, INC. | 1,356,032 | $11.3m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 848,382 | $7.0m | 0.0% |
| Hillsdale Investment Management Inc. | 750,900 | $6.2m | 0.1% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 728,147 | $6.1m | 0.0% |
| TCG Crossover Management, LLC | 707,098 | $5.9m | 0.1% |
| DIMENSIONAL FUND ADVISORS LP | 654,909 | $5.4m | 0.0% |
| GOLDMAN SACHS GROUP INC | 640,811 | $5.3m | 0.0% |
| CITADEL ADVISORS LLC | 620,973 | $5.2m | 0.0% |
| NORTHERN TRUST CORP | 615,296 | $5.1m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 601,873 | $5.0m | 0.0% |
| Nantahala Capital Management, LLC | 600,000 | $5.0m | 0.1% |
| KENNEDY CAPITAL MANAGEMENT LLC | 589,238 | $4.9m | 0.1% |
| Arbiter Partners Capital Management LLC | 589,188 | $4.9m | 1.3% |