| Rosalind Advisors, Inc. | 3,300,389 | $41.6m | 15.4% |
| BlackRock, Inc. | 2,706,802 | $34.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,221,247 | $15.4m | 0.0% |
| Propel Bio Management, LLC | 871,460 | $11.0m | 5.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 733,115 | $9.2m | 0.0% |
| STATE STREET CORP | 679,280 | $8.6m | 0.0% |
| ALGERT GLOBAL LLC | 580,708 | $7.3m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 566,371 | $7.1m | 0.0% |
| Divisadero Street Capital Management, LP | 499,796 | $6.3m | 0.1% |
| MORGAN STANLEY | 407,983 | $5.1m | 0.0% |
| ExodusPoint Capital Management, LP | 359,884 | $4.5m | 0.0% |
| Private Wealth Advisors, LLC | 310,863 | $3.9m | 1.0% |
| Simplify Asset Management Inc. | 264,770 | $3.3m | 0.0% |
| NORTHERN TRUST CORP | 252,108 | $3.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 250,312 | $3.2m | 0.0% |
| ADAR1 Capital Management, LLC | 224,385 | $2.8m | 0.1% |
| MARSHALL WACE, LLP | 218,963 | $2.8m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 210,298 | $2.6m | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 204,143 | $2.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 193,448 | $2.4m | 0.0% |
| Ikarian Capital, LLC | 185,667 | $2.3m | 0.3% |
| VANGUARD FIDUCIARY TRUST CO | 181,903 | $2.3m | 0.0% |
| Nuveen, LLC | 181,595 | $2.3m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 172,993 | $2.2m | 0.0% |
| CIBC WORLD MARKET INC. | 163,208 | $2.1m | 0.0% |