| EcoR1 Capital, LLC | 3,174,519 | $63.9m | 3.1% |
| TCG Crossover Management, LLC | 2,895,304 | $58.3m | 1.4% |
| FMR LLC | 2,054,127 | $41.3m | 0.0% |
| Affinity Asset Advisors, LLC | 2,032,012 | $40.9m | 1.8% |
| BlackRock, Inc. | 1,963,541 | $39.5m | 0.0% |
| Trails Edge Capital Partners, LP | 1,514,000 | $30.5m | 4.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,451,909 | $29.2m | 0.0% |
| Jupiter Topco LLC | 1,091,464 | $22.0m | 0.0% |
| Vestal Point Capital, LP | 1,013,000 | $20.4m | 0.5% |
| Woodline Partners LP | 917,176 | $18.5m | 0.1% |
| Sanofi | 821,917 | $16.5m | 3.1% |
| MORGAN STANLEY | 781,534 | $15.7m | 0.0% |
| 683 Capital Management, LLC | 750,000 | $15.1m | 0.7% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 729,000 | $14.7m | 0.0% |
| Balyasny Asset Management L.P. | 714,948 | $14.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 702,087 | $14.1m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 647,962 | $13.0m | 0.0% |
| STEMPOINT CAPITAL LP | 622,723 | $12.5m | 2.2% |
| Palo Alto Investors LP | 603,489 | $12.1m | 1.7% |
| Sofinnova Investments, Inc. | 565,199 | $11.4m | 0.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 546,992 | $11.0m | 0.0% |
| Nantahala Capital Management, LLC | 500,000 | $10.1m | 0.2% |
| GOLDMAN SACHS GROUP INC | 487,213 | $9.8m | 0.0% |
| Point72 Asset Management, L.P. | 408,330 | $8.2m | 0.0% |
| UBS Group AG | 310,886 | $6.3m | 0.0% |